Originally by: Seetherr
From my understanding of things.. you wouldn't last much out there if you are not
a) in a large group with lots of protection..
b) Solo with a highly skilled character and a fully decked out and armed to the teeth ship.
And from the looks of things even those to requirements dont guarantee you survival all the time lol.
This is not always true, as if you are in a fast frigate such as an interceptor or perhaps a vigil and have instas, you can get past almost any blockade that doesn't have warp bubbles, though you would probably be caught eventually..
To the question, its extremely unlikely that everything hasn't been found, though you may be lucky in some of the systems where no-one ever goes and find a hidden structure or something, but its unlikely to be unique. EVE isn't so good for exploring now, though you can always go look for things yourself and see stuff you haven't personally seen even if others have, sure it may have already been found but if you find it yourself as well its still exploring.
Though I wouldn't personally want to go to 0.0 space as a neutral with just the intent of exploring, all non-alliance (in alliance space anyway) people are classed as hostile, and some other space is just plain nasty.
However, getting to know some people in the space you want to go to and perhaps joining them for a while (good for getting instas which are vital for surviving down there) and exploring then leaving to carry on with EVE if they will let you.