Edited by: foksieloy on 01/09/2011 06:17:14
Notice that you only need to blacklist a few systems, the entry ones.
You can realize which ones are that using dotlan.http://evemaps.dotlan.net/route
Allows you to plan a route avoiding REGIONS. You can use it in ingame browser and have it automatically update with your current location (radar option).http://evemaps.dotlan.net/map/Sinq_Laison
You can see what the entry systems are easilly. Repeat for any other region you might not "like".
Also, consider training Diplomacy, if you haven't already. It will increase your standing with a faction that you have negative standing towards. All you need to do is get it above -5.00